USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: H2AX_HUMAN USC-OGP 2-DE database:  H2AX_HUMAN H2AX_HUMAN General information about the entry View entry in simple text format Entry name H2AX_HUMAN Primary accession number P16104 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Histone H2AX; Short=H2a/x; AltName: Full=Histone H2A.X;. Gene name Name=H2AFX Synonyms=H2AX Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1333: pI=4.59; Mw=16158 SPOT OGP-1335: pI=5.02; Mw=16085 SPOT OGP-1336: pI=5.13; Mw=15865 SPOT OGP-1338: pI=5.68; Mw=15649 Cross-references UniProtKB/Swiss-Prot P16104; H2AX_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name H2AX_HUMAN Primary accession number P16104 Secondary accession number(s) Q4ZGJ7 Q6IAS5 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 181) Name and origin of the protein Description RecName: Full=Histone H2AX; Short=H2a/x; AltName: Full=Histone H2A.X; Gene name Name=H2AFX Synonyms=H2AX Encoded on Name=H2AFX; Synonyms=H2AX Keywords 3D-structure; Acetylation; Cell cycle; Chromosome; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Host-virus interaction; Isopeptide bond; Meiosis; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X14850; CAA32968.1; -; mRNA EMBL CR457079; CAG33360.1; -; mRNA EMBL DQ015918; AAY22178.1; -; Genomic_DNA EMBL BC004915; AAH04915.1; -; mRNA EMBL BC011694; AAH11694.1; -; mRNA EMBL BC013416; AAH13416.1; -; mRNA CCDS CCDS8410.1; -; . PIR S07631; S07631; . RefSeq NP_002096.1; NM_002105.2; . UniGene Hs.477879; -; . PDB 1YDP; X-ray; 1.90 A; P=78-86 PDB 2AZM; X-ray; 2.41 A; C/D=134-143 PDB 2D31; X-ray; 3.20 A; C/F=78-86 PDB 2DYP; X-ray; 2.50 A; C=78-86 PDB 3SHV; X-ray; 2.10 A; C/D=134-143 PDB 3SQD; X-ray; 2.15 A; C/D=134-143 PDB 3SZM; X-ray; 2.63 A; I/J/K/L/M/N/O/P=134-143 PDB 3U3Z; X-ray; 1.50 A; B=140-143 PDBsum 1YDP; -; . PDBsum 2AZM; -; . PDBsum 2D31; -; . PDBsum 2DYP; -; . PDBsum 3SHV; -; . PDBsum 3SQD; -; . PDBsum 3SZM; -; . PDBsum 3U3Z; -; . ProteinModelPortal P16104; -; . SMR P16104; -; . BioGrid 109268; 293; . DIP DIP-33604N; -; . IntAct P16104; 172; . MINT MINT-1338182; -; . STRING 9606.ENSP00000364310; -; . iPTMnet P16104; -; . PhosphoSitePlus P16104; -; . SwissPalm P16104; -; . BioMuta H2AFX; -; . DMDM 121992; -; . EPD P16104; -; . MaxQB P16104; -; . PaxDb P16104; -; . PeptideAtlas P16104; -; . PRIDE P16104; -; . TopDownProteomics P16104; -; . Ensembl ENST00000375167; ENSP00000364310; ENSG00000188486; . Ensembl ENST00000530167; ENSP00000434024; ENSG00000188486; . GeneID 3014; -; . KEGG hsa:3014; -; . UCSC uc001pvg.4; human; . CTD 3014; -; . DisGeNET 3014; -; . GeneCards H2AFX; -; . HGNC HGNC:4739; H2AFX; . HPA CAB012264; -; . HPA HPA041189; -; . HPA HPA051647; -; . MIM 601772; gene; . neXtProt NX_P16104; -; . OpenTargets ENSG00000188486; -; . PharmGKB PA29116; -; . eggNOG KOG1756; Eukaryota; . eggNOG COG5262; LUCA; . GeneTree ENSGT00760000118934; -; . HOGENOM HOG000234652; -; . HOVERGEN HBG009342; -; . InParanoid P16104; -; . KO K11251; -; . OMA TVGPKTP; -; . OrthoDB EOG091G0XGD; -; . PhylomeDB P16104; -; . TreeFam TF300137; -; . Reactome R-HSA-1221632; Meiotic synapsis; . Reactome R-HSA-171306; Packaging Of Telomere Ends; . Reactome R-HSA-201722; Formation of the beta-catenin:TCF transactivating complex; . Reactome R-HSA-212300; PRC2 methylates histones and DNA; . Reactome R-HSA-2299718; Condensation of Prophase Chromosomes; . Reactome R-HSA-2559580; Oxidative Stress Induced Senescence; . Reactome R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP); . Reactome R-HSA-2559586; DNA Damage/Telomere Stress Induced Senescence; . Reactome R-HSA-3214858; RMTs methylate histone arginines; . Reactome R-HSA-427359; SIRT1 negatively regulates rRNA Expression; . Reactome R-HSA-427389; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; . Reactome R-HSA-427413; NoRC negatively regulates rRNA expression; . Reactome R-HSA-5250924; B-WICH complex positively regulates rRNA expression; . Reactome R-HSA-5334118; DNA methylation; . Reactome R-HSA-5578749; Transcriptional regulation by small RNAs; . Reactome R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis; . Reactome R-HSA-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; . Reactome R-HSA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; . Reactome R-HSA-5693571; Nonhomologous End-Joining (NHEJ); . Reactome R-HSA-5693607; Processing of DNA double-strand break ends; . Reactome R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere; . Reactome R-HSA-69473; G2/M DNA damage checkpoint; . Reactome R-HSA-73728; RNA Polymerase I Promoter Opening; . Reactome R-HSA-73777; RNA Polymerase I Chain Elongation; . Reactome R-HSA-912446; Meiotic recombination; . Reactome R-HSA-977225; Amyloid fiber formation; . SIGNOR P16104; -; . ChiTaRS H2AFX; human; . EvolutionaryTrace P16104; -; . GeneWiki H2AFX; -; . GenomeRNAi 3014; -; . PRO PR:P16104; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000188486; -; . CleanEx HS_H2AFX; -; . Genevisible P16104; HS; . GO GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0001673; C:male germ cell nucleus; IEA:Ensembl; . GO GO:0000790; C:nuclear chromatin; IBA:GO_Central; . GO GO:0016607; C:nuclear speck; IDA:HPA; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0000786; C:nucleosome; IEA:UniProtKB-KW; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005657; C:replication fork; IEA:Ensembl; . GO GO:0035861; C:site of double-strand break; IDA:MGI; . GO GO:0001741; C:XY body; IEA:Ensembl; . GO GO:0003684; F:damaged DNA binding; IEA:Ensembl; . GO GO:0003677; F:DNA binding; NAS:UniProtKB; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0042393; F:histone binding; IPI:UniProtKB; . GO GO:0006974; P:cellular response to DNA damage stimulus; IDA:BHF-UCL; . GO GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl; . GO GO:0090398; P:cellular senescence; IEA:Ensembl; . GO GO:0021987; P:cerebral cortex development; IEA:Ensembl; . GO GO:0006342; P:chromatin silencing; IBA:GO_Central; . GO GO:0000077; P:DNA damage checkpoint; IDA:UniProtKB; . GO GO:0006302; P:double-strand break repair; NAS:UniProtKB; . GO GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:Reactome; . GO GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW; . GO GO:0006334; P:nucleosome assembly; NAS:UniProtKB; . GO GO:0045739; P:positive regulation of DNA repair; NAS:UniProtKB; . GO GO:0010212; P:response to ionizing radiation; NAS:UniProtKB; . GO GO:0007283; P:spermatogenesis; IEA:Ensembl; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.10.20.10; -; 1; . InterPro IPR009072; Histone-fold; . InterPro IPR002119; Histone_H2A; . InterPro IPR007125; Histone_H2A/H2B/H3; . InterPro IPR032454; Histone_H2A_C; . InterPro IPR032458; Histone_H2A_CS; . Pfam PF00125; Histone; 1; . Pfam PF16211; Histone_H2A_C; 1; . PRINTS PR00620; HISTONEH2A; . SMART SM00414; H2A; 1; . SUPFAM SSF47113; SSF47113; 1; . PROSITE PS00046; HISTONE_H2A; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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